Antidote paracetamol toxicity5/13/2023 ![]() ![]() We based our review on a PubMed search for articles on paracetamol (or acetaminophen) and acetylcysteine or ( N- acetylcysteine) published between 1 January 1990 and 31 December 2010, without language limits. However, young and otherwise healthy patients still risk serious liver injury, especially if they present more than a few hours after overdose or take staggered overdoses over hours or days.4 Nevertheless, paracetamol poisoning is common and potentially fatal.1 It is a leading cause of acute liver failure in the United Kingdom2 and the United States.3 Potential liver damage, predicted from blood paracetamol concentration and time from ingestion, can be prevented by prompt treatment with antidote. ![]() Paracetamol (acetaminophen) is an effective oral analgesic, with few adverse effects when used at the recommended dose.
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